Margarete Pratschke studied Art History, Modern History and Journalism & Communication Studies in Berlin. From 2004 to 2010 she was a Research Associate in »The Technical Image«, a department of the Hermann von Helmholtz Centre for Cultural Techniques at the Humboldt-Universität zu Berlin, and a member of the editorial team for »Image Worlds of Knowledge: Art History Yearbook of Image Criticism«. She also served as a member of staff in the School of Design Thinking at the Hasso Plattner Institute at the University of Potsdam from 2008 to 2009. She completed her thesis »Windows as a Tableau. On the Visual History of Graphical User Interfaces« in 2011.
She served as Assistant to the Chair for Science Studies at ETH Zurich from 2010 to 2017, and was promoted to Senior Assistant in 2016. From 2010 to 2013 she was a staff member at »eikones«, NCCR Iconic Criticism (University of Basel/ ETH Zurich), where she worked in the module »Perception, Implicit Pictorial Knowledge and Cognition«. She has been an Associated Member of the History of Knowledge Centre in Zurich since 2015. From October 2013 to January 2014 she served as a Fellow in the Excellence Cluster »Image Knowledge Gestaltung. An Interdisciplinary Laboratory« at the Humboldt-Universität zu Berlin. She has been working on the research project »Looking at Pictures. Ways of Understanding Images and Perception in Psychology and Art History« since February 2014. Her monograph on gestalt experiments with images at the Psychological Institute in the Berlin Palace and the avant-garde (»Gestaltexperimente unterm Bilderhimmel. Das Psychologische Institut im Berliner Stadtschloss und die Avantgarde«) appeared in 2016. She was awarded the Caroline von Humboldt Prize in 2016.